Fruit Fly Study Shows Psilocybin Produces Long-Lasting Antidepressant-Like Effect

Fruit Fly Study Shows Psilocybin Produces Long-Lasting Antidepressant-Like Effect
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A recently published study has found that psilocybin can have a long-lasting effect similar to antidepressants in fruit flies, bolstering evidence that the psychoactive compound found in magic mushrooms may one day be used to treat serious mental health conditions in humans. Charles D. Nichols, a professor of pharmacology at the Louisiana State University Health Sciences Center in New Orleans and one of the study’s authors, said that research with fruit flies can support investigations into other animal organisms including mammals. “I have been studying fruit flies since my Ph.D. dissertation work, and have looked at the effects of psychedelics and serotonin receptor drugs in them as part of my overall research program ever since,” Nichols told PsyPost. “Serotonins and their receptors in flies are involved in several key behaviors shared with mammals and humans, including many aspects of social interaction, and learning and memory,” Nichols added. “Fruit flies represent a powerful genetic model to elucidate mechanisms of drug effects and behaviors at the cellular level, and allow for more rapid discovery than in mammalian systems.” Previous research has shown that psilocybin seems to have an antidepressant effect. A study published in 2020 showed that psilocybin can be an effective and quick-acting treatment for major depressive disorder. Most participants showed a substantial decrease in depression after treatment, and more than half were considered to be in remission from depression four weeks after treatment. Among the 24 patients, 67% showed a more than 50% reduction in depression symptoms after one week, and 71% showed similar progress at four weeks. “The magnitude of the effect we saw was about four times larger than what clinical trials have shown for traditional antidepressants on the market,” said study co-author Alan Davis of Johns Hopkins University. No, Fruit Flies Don’t Get Depressed To conduct the…

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Source : Fruit Fly Study Shows Psilocybin Produces Long-Lasting Antidepressant-Like Effect

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