Cannabinoids Stop COVID-19 From Infecting Cells, Study Finds

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Two non-psychoactive cannabinoids found in most cannabis strains have the potential to ward off COVID-19, according to a new study in the Journal of Natural Products[i]. The fact that the research was carried out in a petri dish rather than in live patients means it’s too early to say whether smoking weed or consuming edibles will actually protect against the virus. However, results do at least suggest that these compounds may have a role to play in the development of new treatments for coronavirus. Related Post High-CBD Cannabis Strains May Protect Against COVID How Cannabinoids Fight COVID-19 In a nutshell, the study authors found that two cannabinoids in hemp appear to bind to the spike protein on the surface of the COVID-19 virus, thus preventing it from being able to enter cells. Under normal conditions, this spike protein acts like a kind of hook that latches onto an enzyme in cell membranes called ACE2, triggering a cascade of effects that ultimately results in cells becoming infected with the virus. However, using a technique called affinity selection mass spectrometry, researchers from Oregon State’s Global Hemp Innovation Centre found that cannabigerolic acid (CBGA) and cannabidiolic acid (CBDA) – the precursors to cannabigerol (CBD) and cannabidiol (CBD) – have a natural binding affinity for this spike protein. This led them to suspect that these cannabinoids may be able to inhibit COVID-19. To test their theory, the study authors introduced SARS-CoV-2 – the virus that causes COVID-19 – to human endothelial cells in a petri dish. When they added CBDA and CBGA, they noted that the virus became unable to enter and infect these cells. Can Cannabinoids Actually Treat COVID-19 Highlighting the importance of this finding, study author Richard van Breemen explained that “any part of the infection and replication cycle is a potential…

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Source : Cannabinoids Stop COVID-19 From Infecting Cells, Study Finds

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