Cannabis is a Key Weapon in Fighting Arthritis Pain and Inflammation


Cannabinoids work on CB2 receptors to reduce pain and inflammation of arthritis. Recent studies indicate medical cannabis eases the pain and inflammation of rheumatoid arthritis (RA) and osteoarthritis (OA). Cannabinoids, like THC and CBD, are anti-inflammatory agents that reduce swelling and inflammation in the joints of arthritic patients. Additionally, there have been increasing numbers of laboratory studies performed on cells (in vitro) and in animals (in vivo) that suggest cannabinoids may also have a therapeutic benefit for the arthritic inflammation of RA and OA. RA and OA have common joint destruction and inflammation in the lining of the joint. However, RA involves an autoimmune response that contributes to the worsening of joint destruction. Increased Cannabinoid Receptors Found in Arthritic Inflammation In RA, inflammation of the joint tissue causes abnormal growth of cells called Fibroblastlike Synoviocytes (FLSs). These cells produce a large number of pro-inflammatory proteins, or cytokines, and matrix metalloproteases (MMPs). The cytokines frequently studied in the progression of RA are: interleukins (IL) (like IL-1, IL-6, and IL-8) and tumor necrosis factor (TNF-α). The increased numbers of cytokines trigger an autoimmune response. Immune cells, in particular T-cells, then enter into the joint. These immune cells produce even more pro-inflammatory cytokines, resulting in an increasing of the inflammation. As a result, the joint begins to break down because the immune response increases the formation of osteoclasts. These are special cells that break down and absorb bone. CB2 receptors and 2-AG are found in the joint tissues of patients with arthritic inflammation, but not in healthy subjects. The endocannabinoids, anandamide and 2-AG, are produced naturally in the body, and so this data suggests that the endocannabinoid system is likely part of an anti-inflammatory feedback loop. In other words, receptors in the endocannabinoid system strengthen anti-inflammatory effects. CB2 Receptors and the Inflammatory Response…

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Source : Cannabis is a Key Weapon in Fighting Arthritis Pain and Inflammation

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