Oregon: OHA Advisory Board Releases Psilocybin Rapid Evidence Review and Recommendations


As part of the rule-making and review process under Measure 109 (passed last year and allowing certain types of psilocybin therapies), the Oregon Health Authority (OHA) has commissioned a review of the scientific literature surrounding the benefits of psilocybin, as well as issues around product testing and manufacturing. The results of the initial literature review have been released and are available on the OHA’s website. The review committee looked at several issues related to psilocybin, including: Evidence for efficacy of treatment of various mental health issues; Sources of psilocybin; and Testing Treatment The evidence review tended to show that psilocybin had a positive impact on persons suffering from depression, anxiety, end-of-life issues, and potentially addiction including alcohol use disorder. Side effects were usually mild and transient. Some studies had a weaker design, including smaller sample sizes, or lack of double-blind or randomization, and care should be taken in relying too much on these studies alone. The results of the studies taken together, however, point toward more promising information down the road. Sources of Psilocybin Psilocybin can come from mushrooms, either wild or cultivated, cell cultures, or synthetics. Much of the current testing uses synthetic psilocybin, although there is also a long history of use of whole mushrooms in a variety of cultures and locations around the globe. Both entail some trade-offs. Whole mushrooms are harder to control for dosing due to the high variability between species of mushroom, and even sometimes between individual mushrooms. However, extracted or synthetic psilocybin may also need to be monitored for contaminants. Testing Whether whole mushrooms or extracted psilocybin is used, testing will be required for both contaminants and potency. These include biological agents from the growth medium (compost and dung are particularly problematic), pesticides, herbicides, extraction chemicals, heavy metals in the growth medium, among others.…

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Source : Oregon: OHA Advisory Board Releases Psilocybin Rapid Evidence Review and Recommendations

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