How to Prevent Dementia: The Role of Cannabinoid Therapy

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Research into how to prevent dementia shows THC may not only destroy amyloid plaques, but also prevent formation. Neurotoxic plaques invade the brains of patients with Alzheimer’s Disease. These are made from fibrils of a protein called amyloid-beta peptides. Importantly, plaques appear to prevent proper nerve signalling and this disrupts memory and cognitive functioning. But, THC may be able to stop these fibrils from growing, and may even break down fully formed plaques. Perhaps our quest into how to prevent dementia will soon include cannabinoid therapy. At this time, there is no cure for Alzheimer’s and approved medications don’t help after a certain stage.  Available pharmaceuticals include galantamine, rivastigmine, and donepezil. These are cholinesterase inhibitors prescribed for mild to moderate Alzheimer’s symptoms. Additionally, in June 2021, the FDA approved a pharmaceutical called Aducanumab. It is a type of immunotherapy that targets amyloid plaque deposits directly and may slow the progression of Alzheimer’s. Even with all of these weapons in the arsenal, we still do not yet know how to prevent dementia. There is scientific speculation, however, that cannabis could be a future treatment for exactly this. How to Prevent Dementia: The Endocannabinoid System As mentioned, the hallmark of Alzheimer’s include the formation of fibril tangles and loss of brain cells, leading to cognitive deficits. And it is here that cannabis research is most focussed. In fact, cannabinoid signaling may regulate the pathology of Alzheimer’s disease (AD). This information comes from post-mortem examinations of human AD patients, published in the journal Molecular Pharmaceutics (2008). [1]L Eubanks, C Rogers, A Beuscher, G Koob, A Olson, T Dickerson, K Janda. A Molecular Link Between the Active Component of Marijuana and Alzheimer’s Disease Pathology. Mol Pharm (2008). 3(6): … Continue reading jQuery(‘#footnote_plugin_tooltip_7515_2_1’).tooltip({ tip: ‘#footnote_plugin_tooltip_text_7515_2_1’, tipClass: ‘footnote_tooltip’, effect: ‘fade’, predelay: 0, fadeInSpeed: 200, delay: 400, fadeOutSpeed: 200, position: ‘top…

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Source : How to Prevent Dementia: The Role of Cannabinoid Therapy

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