Could a Cannabis-Derived Spray Successfully Treat Brain Tumours?

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Groundbreaking clinical trials in the UK are poised to explore the effects of cannabis-based oral treatment on patients with recurrent brain tumours. The drug, Sativex, which contains a mixture of THC and CBD, is available as a mouth spray and was previously approved by the UK’s National Health Service in 2019 as a treatment for muscle spasms linked to multiple sclerosis. The NHS now seeks to trial the spray alongside chemotherapy medication temozolomide in a bid to kill cancerous cells in glioblastoma, an aggressive type of cancer that occurs in the brain or the spinal cord. With an incidence rate of around 1 in 10,000, glioblastoma is among the rarest forms of cancer. Still, representing 16% of all primary brain tumours, it’s the most common brain malignancy and is almost always lethal. The Brain Tumour Charity has launched an appeal for funding, hoping to raise £450,000 to finance the trial scheme, which would run for three years. If successful, the drug would represent the first breakthrough in the treatment of glioblastoma in over a decade. How Sativex is Used Sativex contains two chemical extracts found in cannabis: delta-9 THC and cannabidiol, and at present, it is delivered as an oromucosal spray. The number of sprays is increased gradually until the optimum dose is reached, over the course of days up to two weeks, depending on the recipient. In Multiple Sclerosis-related symptoms, Sativex gives relief from muscle stiffness with few side effects(i). The trial represents a landmark moment in cancer treatment via cannabis extracts, as, at present, this remains unapproved in the UK. Success could mean a green light from the medical community, and that could open the floodgates for a host of new cannabis-based treatments across a broad spectrum of conditions, as well as hope for cancer patients. At present,…

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Source : Could a Cannabis-Derived Spray Successfully Treat Brain Tumours?

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