Mutations in the Endocannabinoid System and Biological Causes of Anxiety


Mutations in the endocannabinoid system (ECS) may be one of the biological causes of anxiety. Changes to the Endocannabinoid System (ECS) are being found in a number of neurological diseases, such as Parkinson’s disease, Huntington’s disease and Multiple Sclerosis. Further, an important aspect of a well-functioning ECS is a proper balance between the signaling molecules anandamide (AEA) and 2-arachidonylglycerol (2-AG), and the enzymes that break them down. This balance is missing in many types of disease. In fact, some common mutations in the components of the ECS are causing symptoms of disease, including anxiety. This leads to the question – are these malfunctions in the ECS the biological causes of anxiety? Several studies have set out to answer this question. Could Genetic Mutations be One of the Biological Causes of Anxiety? A rodent study, published in PLoS One (2017), [1]Douglas R Smith, Christine M. Stanley, Theodore Foss, Richard G. Boles, Kevin McKernan. Rare Genetic Variants in the Endocannabinoid System: Genes CNR1 and DAGLA are Associated with Neurological … Continue reading jQuery(‘#footnote_plugin_tooltip_38345_2_1’).tooltip({ tip: ‘#footnote_plugin_tooltip_text_38345_2_1’, tipClass: ‘footnote_tooltip’, effect: ‘fade’, predelay: 0, fadeInSpeed: 200, delay: 400, fadeOutSpeed: 200, position: ‘top center’, relative: true, offset: [-7, 0], }); examined mutations in genes coding for parts of the ECS. They looked specifically at the genes called: CNR1, CNR2, FAAH and MGLL. Additionally, researchers probed how these genes appear in various neurological disorders. Importantly, these genes encode the CB1 receptor, CB2 receptor, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase. In order to study these, the researchers sought out genetic sequencing data from 6,000 individuals. They then compared the data of these individuals to the mutations in these genes. The results for CNR1 reveal significant associations between the presence of the mutations and appearance of anxiety disorders. Significantly, the individuals with the mutations in the gene encoding CB1 receptor were three…

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Source : Mutations in the Endocannabinoid System and Biological Causes of Anxiety

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