Everything You Need To Know About THCV

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Similar in both structure and name to THC, tetrahydrocannabivarin (THCV) produces an array of effects that differ greatly from those of its more famous cousin. Typically occurring in trace amounts in cannabis, this fascinating cannabinoid has begun to attract a great deal of attention, encouraging breeders to develop cultivars that contain higher amounts of THCV. Related Post Cannabis Chemistry And Ambivalent Effects What Is THCV? While THC is an agonist of the CB1 receptor, THCV acts as an in inverse agonist, meaning it binds to the same receptor but produces an opposite pharmacological effect. Unlike THC, therefore, it is non-psychoactive and suppresses the munchies, with some research suggesting that it can even cancel out the effects of THC. In one study, cannabis users were given an oral dose of THCV shortly before being injected with THC, with the result being that none of them got particularly high[i]. However, because THCV occurs in such low concentrations in most cultivars, it’s pretty hard to ingest enough of it to counteract the effects of THC in the real world. Interestingly, THCV also binds to CB2 receptors, leading to suggestions that it could help reduce inflammation, treat pain and possibly even protect against dementia. The Benefits Of THCV Because it suppresses the appetite, THCV is currently being studied as a possible treatment for obesity. Research has shown that it helps to decrease food intake and trigger weight loss, while human trials have indicated that the cannabinoid alters the brain’s response to food[ii]. One study on humans with type 2 diabetes showed that THCV helps to control blood glucose levels, in part by interacting with a hormone called adiponectin, which regulates plasma glucose and fatty acid breakdown[iii]. This capacity to modulate key metabolic processes has been demonstrated in a number of animal studies[iv], indicating that…

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