McGill researchers discover one of the possible mechanisms behind LSD’s ability to boost sociability

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Lysergic acid diethylamide (LSD) research from McGill University could have therapeutic applications in treating some psychiatric disorders, including anxiety, according to findings published in the journal PNAS . Microdosing LSD as a means to boost creativity and productivity has become popular in recent years, but, until now, the “mechanism of action” had remained elusive, note the researchers. Mind Medicine announces study evaluating effects of microdosing LSD This pharmaceutical company has developed an ‘off-switch’ for LSD trips Forget taking a pill a day. Canada is using psychedelics to revolutionize the way we treat mental health and addiction Using a mice model, researchers observed a boost in the sociability of mice after administering low doses of LSD over a seven-day period. “This increased sociability occurs because the LSD activates the serotonin 5-HT 2A receptors and the AMPA receptors — which is a glutamate receptor, the main brain excitatory neurotransmitters — in the prefrontal cortex and also activates a cellular protein called mTORC 1,” Danilo De Gregorio, the study’s lead author, explains in a news release from McGill . According to Nahum Sonenberg, a professor in the Department of Biochemistry at McGill University, the novelty of the research is identifying that “the prosocial effects of LSD activate the 5-HT 2 receptors, which, in turn, activate the excitatory synapses of the AMPA receptor as well as the protein complex mTORC1.” Sonenberg says that these brain pathways are dysregulated in mental disorders that impact sociability. The researchers now hope to determine if microdoses of LSD could have a similar effect in humans and serve as a viable treatment option for some mental health conditions. “Social interaction is a fundamental characteristic of human behaviour,” says co-lead author Dr. Gabriella Gobbi, a Department of Psychiatry professor and psychiatrist at the McGill University Health Centre. “These hallucinogenic compounds,…

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Source : McGill researchers discover one of the possible mechanisms behind LSD’s ability to boost sociability

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