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The general idea of using cannabis and antidepressants is to bring about synergistic action between the drugs. Though there are limited studies on the topics, early signs show the possibility of this effect. Cannabis works in the body through the endocannabinoid system which has a huge role to play in the regulation of mood in the body. The endocannabinoid system contains special cannabinoid receptors, endocannabinoids, and enzymes that work to modulate the system. Different cannabinoids from cannabis work through this system to help promote elevated moods and relaxation.

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Source : Cannabis and Antidepressants – Can You Mix Them Together or Better Not?

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