New study reveals how LSD affects the brain at the molecular level

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A recent study published in the peer-reviewed journal Cell reveals, for the first time, how lysergic acid diethylamide (LSD) and other psychedelic drugs impact the brain at the molecular level. With psychedelic medicines once again gaining popular momentum , the team of researchers, led by Dr. Bryan Roth, a pharmacologist and psychiatrist at the University of North Carolina School of Medicine, set out to better understand the impact of LSD on the brain. Bruce Linton talks cannabis, psychedelics, and why he’s ‘unemployable’ People are increasingly open to psychedelic therapies. What’s driving that change? Forget taking a pill a day. Canada is using psychedelics to revolutionize the way we treat mental health and addiction Using electron microscopy techniques and X-ray crystallography, the researchers discovered that an amino acid, part of the protein, Gαq, appears to be the switch that activates the psychedelic experience, reports Big Think . “Now we know how psychedelic drugs work — finally! Now we can use this information to, hopefully, discover better medications for many psychiatric diseases,” Dr. Roth said. The ultimate goal of the research, he said, “is to see if we can discover medications which are effective, like psilocybin, for depression, but do not have the intense psychedelic actions.” There is a growing movement attempting to harness the therapeutic elements of psychedelic substances while eliminating the hallucinogenic effects. The Bruce Linton-backed Mind Medicine Inc. is one such company. The first product in its pipeline is 18-MC, a derivative of Ibogaine, which has shown promise in treating heroin, alcohol, methamphetamine and opioid addiction. In its natural state, Ibogaine can induce uncomfortable hallucinations and, in some cases, be toxic to the heart and fatal even months after ingestion. MindMed’s product is non-toxic and non-hallucinogenic, but is believed to maintain Ibogaine’s anti-addictive properties. “It’s neuro medicine,” Linton told…

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Source : New study reveals how LSD affects the brain at the molecular level

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