New Study Reveals How CBD Blocks Pain Signalling Pathways

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While the therapeutic applications of cannabidiol (CBD) are extremely broad, the cannabinoid’s ability to reduce pain has become one of its major attractions. A recent survey of medical cannabis users found that some 53 percent use marijuana specifically for pain relief[i], and research is still ongoing in order to determine exactly how the various compounds in cannabis produce this effect. On that front, a team of scientists from Imperial College London have just published a new study in the Journal of Pain Research, revealing how CBD desensitises certain neurons that are involved in pain signalling[ii]. Related Post Pain No More: The Best Cannabis Strains For All Kinds Of Pain Relief Blocking The Pain Pathway Previous studies have found that the painkilling effects of CBD can be weakened by blocking serotonin receptors in the brains of mice, indicating that the cannabinoid’s analgesic capacity is mediated at least in part by these receptors[iii]. However, to gain a more rounded idea of how the cannabinoid works, the authors of this latest study decided to focus on a different receptor known as the transient receptor potential vanilloid 1 (TRPV1), which is known to play a key role in pain signalling. The researchers began by culturing neurons in a petri dish and adding capsaicin, the compound in chillies which gives them their spicy heat. In response, TRPV1 receptors in these neurons became activated, sending out pain signalling molecules that would normally lead to the kind of burning sensation that results from eating food that’s a bit too spicy. When these neurons were treated with CBD, however, they became noticeably less sensitive to capsaicin, and transmitted fewer pain signals after coming into contact with the fiery compound. Closer analysis revealed that this occurred because CBD inhibited a secondary molecule called cyclic adenosine monophosphate (cAMP), which is…

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Source : New Study Reveals How CBD Blocks Pain Signalling Pathways

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